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Protease inhibitors and breast cancer prevention

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For women with a higher than average risk of breast cancer who are considering taking medicine to lower their risk , drugs called aromatase inhibitors AIs may be an option instead of tamoxifen or raloxifene. Estrogen can fuel the growth of breast cancer cells. Because of this, they are used mainly in women who are past menopause. AIs are used mainly to treat women with hormone receptor-positive breast cancer.
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Phase I Study of Aprotinin in Advanced Breast Cancer

Protease inhibitors and breast cancer prevention
Protease inhibitors and breast cancer prevention
Protease inhibitors and breast cancer prevention
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Protease Inhibitors as Cancer Chemopreventive Agents | A.R. Kennedy | Springer

Optimization of two amino acids green of the natural trypsin inhibitor BPTI gray ribbon, top produced an improved inhibitor with structural complementarity to mesotrypsin beige. Mesotrypsin, encoded by the PRSS3 gene, is a human serine protease whose upregulation has been implicated in promoting tumor progression. Mesotrypsin inhibitors could offer valuable tools for deciphering the pathological role of this enzyme and could also form the basis for novel therapeutic strategies targeting mesotrypsin. Radisky's Proteases in Cancer Laboratory is developing mesotrypsin inhibitors and evaluating their therapeutic potential in preclinical models of breast cancer, pancreatic cancer, prostate cancer and lung cancer. Mesotrypsin inhibitors could offer a new approach to slowing cancer cell malignant growth, invasion and metastasis.
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Protease Inhibitors as Cancer Chemopreventive Agents

Objective: To review the mechanisms of anti-cancer activity of nelfinavir and other protein inhibitors PIs based on evidences reported in the published literature. Methods: We extensively reviewed the literature concerning nelfinavir NFV as an off target anti-cancer drug and other PIs. A classification of PIs based on anti-cancer mode of action was proposed.
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Proteasome inhibitors are emerging as a new class of chemopreventive agents and have gained huge importance as potential pharmacological tools in breast cancer treatment. Improved understanding of the role played by proteases and their specific inhibitors in humans offers novel and challenging opportunities for preventive and therapeutic intervention. In contrast, BTCI exhibited no cytotoxic effect on normal mammary epithelial cells. Moreover, the increased levels of intracellular reactive oxygen species ROS and changes in the mitochondrial membrane potential in cells treated with BTCI indicated mitochondrial damage as a crucial cellular event responsible for the apoptotic process.
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