B cells , also known as B lymphocytes , are a type of white blood cell of the lymphocyte subtype. B cells, unlike the other two classes of lymphocytes, T cells and natural killer cells , express B cell receptors BCRs on their cell membrane. B cells develop from hematopoietic stem cells HSCs that originate from bone marrow. B cells undergo two types of selection while developing in the bone marrow to ensure proper development, both involving B cell receptors BCR on the surface of the cell. To complete development, immature B cells migrate from the bone marrow into the spleen as transitional B cells , passing through two transitional stages: T1 and T2.
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Types of B-cell Lymphoma
B Cells | British Society for Immunology
Acute lymphocytic leukemia ALL is a fast-growing cancer of lymphocyte-forming cells called lymphoblasts. There are several subtypes of ALL, which are based mainly on:. Most often in children with ALL, the leukemia starts in early forms of B cells. There are several subtypes of B-cell ALL.
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B Cells: Antibody Producing Immune Cells
Early B cell development and commitment to the B cell lineage occurs in the foetal liver prenatally, before continuing in the bone marrow throughout life. B cells are at the centre of the adaptive humoral immune system and are responsible for mediating the production of antigen-specific immunoglobulin Ig directed against invasive pathogens typically known as antibodies. Several distinct B-cell subsets have been defined that possess distinct functions in both adaptive and innate humoral immune responses.
It has long been appreciated that highly autoreactive BCRs are actively removed from the developing B cell repertoire by Ag-dependent receptor editing and deletion. However, there is persistent debate about whether mild autoreactivity is simply tolerated or positively selected into the mature B cell repertoire as well as at what stage, to what extent, under what conditions, and into which compartments this occurs. In this study, we describe two minor, trackable populations of B cells in Bi Ig transgenic mice that express the VH The less autoreactive of these two populations is strongly counterselected during the development of mature B1a, follicular, and marginal zone B cells.
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